A 50th video presents a one-pot synthesis of a phenethylamine ketone (ephedrone analog) from propiophenone, incorporating piperidine. The route involves forming an alpha-bromo ketone via bromination, followed by nucleophilic substitution with piperidine to yield the target amine. The procedure includes aqueous/organic workups, acid-base extractions, and crystallization to isolate the product as a free base and then as a hydrochloride salt. The total isolated yield is about 0.85 g (roughly 35% of the starting propiophenone). Safety notes warn that the alpha-bromo intermediate is highly hazardous and that the product is unlikely to be pharmacologically active; a secondary amine is used to avoid formation of pyrazines.
