tags
sodium bromatebromineDHFbromatetetrahydrofuransulfuric acidDCMdoxygenTHFGammaethanol

video tutorial Sodium bromate oxidation of tetrahydrofuran

Summary of the video content:

  • An attempt to oxidize tetrahydrofuran (THF) with sodium bromate under acidic conditions is described and demonstrated, including small- and larger-scale setups.
  • The initial reaction is slow and requires heating; bromine formation and fumes appear as the reaction progresses, indicating a vigorous oxidation process.
  • The setup includes reflux, condensation, temperature monitoring, and safety measures due to exothermicity and halogen evolution.
  • The reaction is quenched and the mixture is worked up via extractions, drying, and distillation.
  • The distillate is identified as gamma-butyrolactone (GBL), a known sedative drug with abuse potential; its production and distribution are illegal in many countries.
  • The presenters close with safety reflections and a sign-off.

more