video tutorial Separating paracetamol and codeine from strong analgesic tablets

Name: video tutorial - Separating paracetamol and codeine from strong analgesic tablets
Uploaded: 2025-12-11T09:03:44.265Z
Duration: 14 min 41 s
Description: Each tablet contains 500 mg of paracetamol and 30 mg of codeine phosphate....Paracetamol is fairly temperature-stable, but codeine is a delicate substance, so we want to be careful we don't heat it above about 70 degrees C for too long.

Crushes tablets containing paracetamol and codeine phosphate to demonstrate extraction techniques.
Performs aqueous extraction to separate water-soluble components, distinguishing paracetamol from codeine phosphate.
Purifies paracetamol via an ethanol (or similar solvent) extraction, then evaporates solvent to crystallize the product.
Converts codeine phosphate to its free base by controlled pH adjustment and extracts it with an organic solvent, followed by drying and further processing to form codeine hydrochloride.
Reports small-scale yields and discusses safety, regulatory considerations, and the transferability of the methods to other compounds, highlighting essential basic lab skills.