Overview: The text describes a lab synthesis of isopropyl nitrite from isopropanol and a nitrite source in acidic conditions, highlighting the hazards of toxic gas formation and the need for ventilation and cooling.
High-level steps: prepare an aqueous nitrite solution; chill and acidify the alcohol mixture; carefully add the acid–alcohol mix to the nitrite solution at low temperature with stirring; observe formation of nitrogen oxide gases and color changes; complete addition, then work up by removing acid and purifying the product through washing and drying; isolate a reactive, unstable product that should be stored under cool, dark conditions with periodic pressure relief.
Hazards: highly toxic fumes (nitrogen oxides), dizziness and headaches; reaction is exothermic and can build pressure, requiring proper ventilation and venting.
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