video tutorial Piperine hydrolysis to piperinic acid and piperidine

Name: video tutorial - Piperine hydrolysis to piperinic acid and piperidine
Uploaded: 2025-12-11T09:03:44.041Z
Duration: 14 min 31 s
Description: Check out our previous video for details of how we did this.

7 g picorin (piperine) from white pepper used with 5 g potassium hydroxide in 40 mL absolute ethanol; reflux for 3 hours to hydrolyze the amide, forming potassium piperidate and piperidine.
Post-reflux: ethanol distilled to concentrate; potassium piperidate is water-soluble. A 50 mL water wash dissolves the salt; unreacted piperine filtered and washed.
Acidification with concentrated HCl precipitates piperidic acid; 4.6 g obtained (86% yield from starting piperine); aroma described as slightly sweet, pungent bubble gum.
Piperidine isolated as its hydrochloride salt by passing HCl gas through piperidine in ethanol, then evaporating solvent to yield 1.3 g of piperidine hydrochloride (44% yield).
Final products: piperidinic acid and piperidine hydrochloride; starting material peppercorns; small-scale demonstration of lab techniques with potential optimizations discussed (e.g., alternative bases, solvent choices, vacuum improvements).