video tutorial Make p-aminophenol from paracetamol

Name: video tutorial - Make p-aminophenol from paracetamol
Uploaded: 2025-12-11T09:03:43.793Z
Duration: 13 min 25 s
Description: paracetamol from tablets using an organic solvent such as acetone, ethanol or isopropanol....Acetone is our favorite as it's efficient and easy, and evaporates quickly leaving crystals

Overview: The video demonstrates hydrolysis of paracetamol (acetaminophen) to 5-aminophenol via alkali hydrolysis after extracting paracetamol from tablets with acetone.
Procedure: Dissolve paracetamol in sodium hydroxide, heat with stirring to promote hydrolysis, then neutralize with dilute hydrochloric acid to regenerate the free phenol and precipitate 5-aminophenol by cooling.
Observations: Solid dissolves upon heating; pink coloration appears due to oxidation and quinone formation; phenols oxidize readily in alkaline/heated conditions, which can affect purity.
Purification: Crude product purified by recrystallization from warm water, with filtration of insolubles; final dried product obtained as yellow/brown crystals.
Yield and purity: From 5 g starting paracetamol, about 2.8 g of para-aminophenol was obtained (≈78% yield); purification yields brown/impure crystals, highlighting decomposition concerns and impurity removal via hot filtration.
Notes and future work: Consider alternative purification strategies and hydrolysis methods (e.g., dilute acid) for potentially cleaner products; plan to test the process further and explore stability of the product.