tags
isopropanolaspirinacetylsalicylicacetone

video tutorial Acetylsalicylic acid extraction from aspirin tablets

  • Demonstrates a quantitative extraction of acetylsalicylic acid (aspirin) from 48 tablets (each 500 mg) using dry acetone as solvent.
  • Dissolve in 50 mL acetone and heat in a microwave (400 W) to boiling; break up remaining solids and re-boil.
  • Filter the hot solution to remove insoluble tablet binders, using vacuum filtration; return insolubles to the beaker.
  • Add an additional 25 mL acetone to dissolve remaining acetylsalicylic acid and heat again; filter hot.
  • Repeat with the final 25 mL to dissolve any remaining product, then filter again.
  • Crystallization: allow the filtrate to cool and form crystals; filtering at this stage would remove product still dissolved in acetone.
  • Dry the crystals by evaporating the acetone in a warm, ventilated dish; acetone is highly flammable.
  • Within a few hours, acetone evaporates leaving roughly 24 g of pure acetylsalicylic acid crystals (near 100% recovery).
  • A suggested challenge is to maximize yield with minimal solvent.

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