tags
isopropanolaspirinacetylsalicylicacetone
video tutorial Acetylsalicylic acid extraction from aspirin tablets
- Demonstrates a quantitative extraction of acetylsalicylic acid (aspirin) from 48 tablets (each 500 mg) using dry acetone as solvent.
- Dissolve in 50 mL acetone and heat in a microwave (400 W) to boiling; break up remaining solids and re-boil.
- Filter the hot solution to remove insoluble tablet binders, using vacuum filtration; return insolubles to the beaker.
- Add an additional 25 mL acetone to dissolve remaining acetylsalicylic acid and heat again; filter hot.
- Repeat with the final 25 mL to dissolve any remaining product, then filter again.
- Crystallization: allow the filtrate to cool and form crystals; filtering at this stage would remove product still dissolved in acetone.
- Dry the crystals by evaporating the acetone in a warm, ventilated dish; acetone is highly flammable.
- Within a few hours, acetone evaporates leaving roughly 24 g of pure acetylsalicylic acid crystals (near 100% recovery).
- A suggested challenge is to maximize yield with minimal solvent.
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